Tag: "immunoglobulin G"
- Triple J Farms has developed a method of monitoring passive transfer in the newborn llama by using a radial immunodiffusion test. To date we have monitored over 300 mother IgG colostrum titers and the next day serum levels of IgG in the cria. By observation of the cria's activity, weight gain, and general health we have determined what we consider to be adequate IgG levels in the 24 hour cria. A cria may not achieve this level due to a difficult birth, poor milk, improper sucking reflex, lowered body temperature, etc.
- “Sepsis is a severe illness in which the bloodstream is overwhelmed by bacteria”.1 The more accurate diagnostic consequence of sepsis is what is termed Systemic Inflammatory Response Syndrome (SIRS). Regardless of the animal SIRS afflicts, the bacteria must have an entry point into the bloodstream and the animal must be vulnerable. In the newborn cria, the entry into the bloodstream is usually the umbilical cord. Invading bacteria also need a susceptible host.2 In the newborn cria, that immune vulnerability is produced when the cria gets inadequate amounts of colostrom, or poor quality colostrom. Camelids are born with a condition called, in medical terms, agammaglobulinemia. This simply means they are born with no passive immunity acquired during gestation. During the pregnancy, the gestating cria attains no temporary source of immunity to common environmental bacteria through the placenta. The entire source of the camelid immunoglobulin (IgG), or temporary immunity, is acquired from the colostrom the cria ingests in the hours after birth.3 The newborn camelid cria’s immunity to infectious agents is completely dependent on receiving adequate and early doses of colostrom.
- Undetected failure of passive transfer (FPT) of immunoglobulin is a major determinant of mortality in newborn alpaca cria, and early detection with proactive management can reduce mortality rates in cases of suspect FPT. The goal of this prospective observational study was to evaluate maternal serum IgG levels as a predictor for subsequent cria FPT (IgG 2000 mg/dl (n = 13). Analysis of variance within maternal groups revealed significant differences in cria birth IgG levels, whereby the highest levels were observed when dam IgG measured 1000-1499 mg/dl, followed by 1500-2000 mg/dl and cria had the lowest birth IgG levels from dams exhibiting IgG levels > 2000 mg/dl (640 mg/dl, 554 mg/dl and 545 mg/dl respectively). Although there were cria with birth IgG